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Catalysis Letters, Vol.148, No.4, 1254-1262, 2018
Four-Component Synthesis of 2-Amino-3-Cyanopyridine Derivatives Catalyzed by Cu@imineZCMNPs as a Novel, Efficient and Simple Nanocatalyst Under Solvent-Free Conditions
An efficient and convenient method was investigated for synthesis of 2-amino-3-cyanopyridine derivatives via a one-pot four-component reaction of various types of aldehydes, acetophenone, malononitrile, and ammonium acetate in the presence of 10 mg Cu@imineZCMNPs catalyst. The favorable products were achieved with high quantitative yields and easy isolation of products in short reaction times under solvent-free conditions. The prepared catalytic system was characterized by Fourier transform infrared spectroscopy, energy dispersive X-ray, thermogravimetric analysis, X-ray diffraction, transmission electron microscopy, scanning electron microscopy and vibrating sample magnetometer. Due to the magnetic nature of the catalyst, it can be easily recovered by an external magnetic field and comfortable reused. [GRAPHICS] .
Keywords:Heterogeneous catalyst;2-Amino-3-cyanopyridine;Solvent-free conditions;Reusable catalyst;Multicomponent reaction;Vibrating sample magnetometer