Distillation with vapor recompression (VRC) has received much attention in recent years as a technology for enhancing energy efficiency of distillation systems. Various configurations of vapor recompression were proposed in previous studies. A novel system is proposed that utilizes the same concepts, distillation without hot utilities (DWHU). In a DWHU system, water at normal temperatures is the sole source of thermal energy for distillation. In this paper, a set of novel DWHU configurations are proposed and their energy and economic performances are presented and compared with previous systems such as conventional distillation column and VRC. Seven configurations (including five DWHU configurations) were studied for separation of a propylene/propane mixture. From both energy and economic points of view, it has been revealed that the newly proposed DWHU configuration can outperform conventional distillation, VRC and base DWHU systems.