The existence of estrogenic hormones in water systems has a potential adverse impact on the environment and public health. Cyclodextrin (CD) can encapsulate small molecules to form host-guest complexes with high stability; thus, it is being applied to remove pollutants in water systems. Beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD) have different cavity diameters, which directly affect their inclusion ability. Therefore, it's predicted that there may be a certain difference in the adsorption performance of beta-CD- and gamma-CD-based polymers. In this study, mesoporous polymers of beta-CD and gamma-CD were prepared, and their adsorption efficiency on estrogen pollutants, including 17 beta-estradiol (E2), 17 alpha-ethinylestradiol (EE2), and bisphenol A (BPA), at environmentally relevant concentrations was investigated. The results indicated that both beta-CD polymer (beta-CDP) and gamma-CD polymer (gamma-CDP) exhibited rapid and efficient removal of the three estrogens and maintained high performance after regeneration. The adsorption processes fitted well with the pseudo-second-order and Langmuir isothermal adsorption model. gamma-CDP exhibited better adsorption ability on E2 and EE2 than beta-CDP. These phenomena were further clarified by the inclusion mechanism between CDs and estrogens gained from Job's plot and molecular docking. beta-CD can only embed one estrogen molecule in its cavity, whereas gamma-CD can embed two E2 or EE2 molecules due to its larger cavity. In addition, both beta-CDP and gamma-CDP can efficiently remove other estrogens such as estrone, estriol, diethylstilbestrol, octyl phenol, and nonylphenol. This study showed the potential of CD polymers, especially gamma-CDP, in rapidly and efficiently removing estrogen pollutants.