Flexibility in supply chain networks dealing with uncertainty, has become a research challenge over the past years. This work proposes a flexible supply chain network design (SCND) model that uses generalized production/warehousing nodes instead of individual production plants and warehouses while conquers with demand uncertainty using a scenario-based approach. It also deals with inventory management and decisions on strategical and tactical level (facility location, production rate, warehouse capacity, demand allocation between generalized nodes, inventory levels, product flows, suppliers' product availability and links between all facilities). The proposed Mixed-Integer Linear Programming (MILP) model allows intra-layer flows between generalized nodes and aims at minimizing total network cost. A case study is formed to test the applicability of the model for a medium sized European company. A comparison was made between a classic supply chain network and generalized network that deals with uncertainty. Results have revealed cost benefits for this model, making it not only applicable, but also cost effective for the company that will apply it. This decision support system, can help managers in taking strategic decisions such as facility location, with a higher level of accuracy. (C) 2017 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.