The present study demonstrated the binary and ternary complexes of Zaltoprofen (ZPF) with beta-CD and HP-beta-CD. The products were characterized using solubility, in vitro dissolution, and DSC studies. The mode of interaction of guest and host was revealed through H-1 NMR and FT-IR studies. A significant increase was noticed in the stability constant (K-c) and complexation efficiency (CE) of beta-CD and HP-beta-CD due to addition of L-Arg in ternary complexes. The ternary complexes showed greater increase in solubility and dissolution of ZPF than binary complexes. Thus, ternary system of ZPF could be an innovative approach for its solubility and dissolution enhancement. (C) 2018 Elsevier B.V. All rights reserved.