The effectiveness of hydrate-formation inhibitors is evaluated to select the best reagents for preventing hydrate formation in gas wells that are active-gas donors for conditions in the eastern part of Orenburg oil and gas condensate fields. A polythermal method that involves cooling at a constant rate of 1A degrees C/h a system consisting of an inhibitor dissolved in simulated strata water and a gas mixture was used for the study. The inhibiting properties of the samples were characterized from the initial hydrate-formation temperature and the amount of gas turned into hydrate at the end of the test.