The wettability and interfacial characterization of -TiAl alloy on TiC0.78, TiN0.87, and VNx substrates were studied using the Sessile Drop method at 1758K. The equilibrium apparent contact angle of liquid -TiAl alloy are 8 degrees on TiC0.78 substrate, 22 degrees on TiN0.87, but deficient for VNx substrate because of the gradual appearance of solidification phenomena. The spreading mechanism of -TiAl/TiC0.78 was ascribed to the product control model, which was determined by the new Ti2AlC formed at the interface. The decreased apparent contact angle of -TiAl on TiN0.87 substrate with the slow rate resulted from the combined effect of Ti adsorption at the interface and the decreased surface tension and viscosity of the liquid. The -TiAl/VNx system was a dissolution system. The effect of dissolution on apparent contact angle is reflected in the initial stage and progressed synchronously with the movement of the triple-phase line. [GRAPHICS]