Thermodynamic modeling in CFD is basically limited to the models available in the simulators. The method presented in this paper connects CFD simulators with Aspen Plus which instantaneously calculates and returns the value of any physical property required. Therefore, all the thermodynamic models and compounds available in Aspen Plus can be implemented in CFD simulations. The connection, created via Matlab and Excel-VBA, has been validated solving two identical CFD simulations first selecting a thermodynamic model available in the simulator and then connecting the simulator with Aspen Plus and selecting the same model. The maximum absolute average deviation between the density and viscosity values obtained in both simulations, for the two case studies analyzed, is lower than 0.7% which demonstrates the proper interconnection. The accuracy of the results obtained modeling multicomponent mixtures and supercritical fluids prove the applicability of the method to any scenarios. (C) 2018 Elsevier Ltd. All rights reserved.