This work presents an integrated framework for fault detection and isolation (FDI) and fault tolerant control (FTC) of variable air volume (VAV) boxes, a common component of heating, ventilation and air conditioning (HVAC) systems. To this end, first a statistical model based FDI framework is designed using existing techniques such as principal component analysis (PCA) and joint angle analysis as a benchmark for comparison. Then a novel linear causal model based framework for FDI of multiple actuator and multiple sensor faults is designed and implemented and shown to possess superior FDI capabilities compared to the statistical model based framework. Finally, a safe parking strategy is designed and the ensuing energy savings for the case of stuck dampers demonstrated. (C) 2017 Elsevier Ltd. All rights reserved.