The effect of (D-)-fructose (fruit sugar), (D+)-galactose and (D+)-lactose (milk sugar) on the solute-solvent interactions occurred between the diphenhydramine-hydrochloride (DPH-HCl) drug and water was studied. To this end, the density, speed of sound and viscosity data for DPH-HCl drug in water and aqueous solutions of (D-)-fructose, (D+)-galactose and (D+)-lactose should have been measured. Thermodynamic properties such as the apparent molar volume (V-phi) and apparent molar isentropic compression (K-s,K-m) were calculated from the density and speed of sound values within sugar molality range of (0.05, 0.1, and 0.15) mol kg(-1) at T = (288.15, 293.15, 298.15, 308.15 and 318.15) K. Extrapolation to the infinite dilution of V-phi and K-s,K-m values with using Redlich-Meyer equation was applied to find the corresponding limiting apparent molar quantities. Jones-Dole equation was used to obtain the viscosity B-coefficients. Interparticle interactions occurred between the DPH-HCl drug and water were determined by calculating the transfer parameters of limiting apparent molar volume and viscosity B-coefficient from DPH-HCl in water to the DPH-HCl in aqueous (D-)-fructose, (D+)-galactose and (D+)-lactose solutions. (C) 2017 Elsevier Ltd.