A micro-scale interface dislocation dynamics approach to model the mechanical behavior of crystalline nanolaminates is presented. To circumvent the exhaustive atomistic modeling of interfaces and dislocations in nanolaminates, an atomistically informed dislocation dynamics model was developed in which interfaces are categorized using a geometrical interface classification scheme and the interface-dominated mechanical response is related to nucleation, glide, and reactions of lattice and interface dislocations at/within/across interfaces. We show that such a scheme is effective in mapping the structure-property relations of various types of interfaces.