Molecular dynamics simulation was used to study the wettability of the hydrophilic sphalerite (110) surface chemically modified by butylthiols made up of normal and branched alkyl tails, referred to as n-butylthiol and i-butylthiol hereafter, at different adsorption site coverages. Butylthiol molecules were grafted onto the adsorption sites of the surface in two different distributions-ordered and random. The results showed that for a given butylthiol at a given site coverage, random surface distribution yielded a slightly larger contact angle. This observation was attributed to the fact that average distances between the first and second nearest neighbors of butylthiol molecules are shorter in the case of random surface distribution, resulting in smaller patches of bare surface exposed to water molecules compared to those of the ordered surface distribution. Regardless of the tail structure, the random surface distribution exhibited hydrophobic character (i.e., contact angle >= 90 degrees) at a relatively low site coverage of about 25%. The test area method and the Kirkwood and Buff approach were adopted to estimate surface energies (gamma(SV)) of the bare sphalerite (110) surface and the collector monolayer, respectively. Using the obtained gamma(SV) values of these two pure states, the apparent surface energy as a function of surface coverage was determined based on Cassie's law. This allowed us to estimate the corresponding values of solid liquid apparent interfacial tension (gamma(SV)). Both gamma(SV) and gamma(SL) exhibit a linear inverse dependence on surface coverage with a crossover point at 25% site coverage (about 50% surface coverage), above which gamma(SV) falls below gamma(SL), leading to contact angles greater than 90 degrees. The results also revealed that contact angles of the two butylthiols are comparable at site coverages below similar to 85%, but above that, they are significantly lower for the branched thiols compared to their normal counterparts. Considering the Lennard-Jones interaction energies between the water cluster and the butylthiols, stronger attractive interactions were present in the case of i-butylthiol due to the presence of two methyl groups in its alkyl chain. This difference was the most intense at site coverages above, similar to 85%.