The active phase plays an important role in the catalytic activity. However, its applicability is directly associated with other present phases in the mixture. In view of this, we report the performance of Ni catalysts dispersed on mixed oxides containing Zn2+, Al3+ and Zr4+ cations in biogas reforming. For this purpose, the samples were characterized by X-ray powder diffraction, which showed the formation of a homogeneous mixture of binary (NiO, ZnO, ZrO2 and Al2O3) and ternary (NiAl2O4 and ZnAl2O4) oxides. The temperature-programmed reduction (H-2-TPR) provided information on the catalyst reduction. The performance of the catalysts was evaluated using two reduction temperatures (650 degrees C and 750 degrees C). The reactions were carried out at 750 degrees C, where the Ni/ZnAlZr catalyst presented the highest CO2 conversion attributed to the basic sites, which favored the CO(2 )adsorption. Otherwise, the Ni/ZnZr catalyst (reduced at 650 degrees C) showed a high CH4 conversion. The catalysts were also reduced at 750 degrees C and a lower conversion of both reactants (CH4 and CO2) was observed. We argued that the agglomeration process during the reduction condition deteriorates the performance of the catalysts reduced at 750 degrees C.