Pleated cartridge filters are widely used to remove dust in industrial processes. However, pulse jet cleaning is not uniform between filter cartridges. This is due to uneven transient pressure below the injection holes leading to the increase of operating resistance and decline in the cleaning cycle, both of which are detrimental to pleated cartridge filter operation. Therefore, the injection pipe plays an important role in pulse-jet cleaning. In order to provide guidance for injection pipe design, a pulse-jet cleaning experimental system was designed. Experiments involved a constant total filtration area under four working conditions; the effects of the injection hole diameter, the number of injection holes, the jet distance, and the tank pressure on pulse jet cleaning were studied by testing the static pressure on the inner wall of the cartridge. This also allowed optimization of the jet distance, orifice ratio, injection hole diameter, and internal cartridge volume. The results showed that 1) the transient pressure below the injection holes increased gradually along the airflow direction of the injection pipe, and 2) the peak positive pressures on the corresponding cartridge inner surfaces also increased. Both of these pressure values increased with increasing tank pressure. Peak positive pressure on the inner wall of the cartridges first increased, and then decreased with increasing jet distance. The injection hole diameter and the optimum jet distance can be described by mathematical models developed from this study. The optimum jet distance decreased with increasing injection hole diameter. The optimum orifice ratio range was 0.6-0.8 under the optimum jet distance, adoption of which improved the pulse jet intensity significantly. Injection hole optimization resulted in gradually decreasing injection hole diameter along the airflow direction of the injection pipe and increased the pulse jet uniformity by a factor of 5-8. The internal volume of the cartridge influenced pulse jet cleaning under constant filtration area. (C) 2018 Elsevier B.V. All rights reserved.