In this paper we consider a control system coupled with a generalized equation, which we call a differential generalized equation (DGE). This model covers a large territory in control and optimization, such as differential variational inequalities, control systems with constraints, as well as necessary optimality conditions in optimal control. We study metric regularity and strong metric regularity of mappings associated with DGE by focusing in particular on the interplay between the pointwise versions of these properties and their infinite-dimensional counterparts. Metric regularity of a control system subject to inequality state-control constraints is characterized. A sufficient condition for local controllability of a nonlinear system is obtained via metric regularity. Sufficient conditions for strong metric regularity in function spaces are presented in terms of uniform pointwise strong metric regularity. A characterization of the Lipschitz continuity of the control part of the solution mapping as a function of time is established. Finally, a path-following procedure for a discretized DGE is proposed for which an error estimate is derived.