화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.62, 239-249, June, 2018
DOI10.1016/j.jiec.2018.01.001  Export Citation
Synthesis and characterization of chitosan ascorbate nanoparticles for therapeutic inhibition for cervical cancer and their in silico modeling
Vigneshkumar Sekar, Karthikeyan Rajendran†, Sugumari Vallinayagam, Venkataraman Deepak1, and Surianarayanan Mahadevan2
  • Department of Biotechnology, Mepco Schlenk Engineering College, Sivakasi 626005, Tamil Nadu, India
  • 1Department of Biotechnology, Kalasalingam University, Anand Nagar, Krishnankoil 626190, Tamil Nadu, India
  • 2Chemical Engineering Department, Central Leather Research Institute (CLRI), Adyar, Chennai 600020, Tamil Nadu, India
E-mail:
This study focuses on synthesis and characterization of chitosan ascorbate nanoparticles (CANs) from a salified carboxylate form of chitosan with ascorbic acid. Evident changes were observed in crystallinity and structure of CANs from their parent polymer. CANs exhibited improved antioxidative properties against DPPH, ABTS, and FRAP. In vitro effect of CANs on cervical cancer cells (HeLa) and noncancer human fibroblast cells (WI-38) viability showed portentous toxic effects on cancer cells with reduced viability on increasing CANs concentration. However, no significant effect was observed in the fibroblast cells. Further, in silico docking on cervical cancer protein targets also showed efficient binding.
Keywords:Chitosan;Ascorbic acid;Chitosan ascorbate nanoparticles;Cytotoxicity;In silico docking
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