화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.63, 348-358, July, 2018
DOI10.1016/j.jiec.2018.02.035  Export Citation
Synthesis and biophysical analysis of a novel gemini surfactant with lysozyme: Industrial perspective
Imtiyaz Ahmad Bhat†, Bibhisan Roy, and Kabir-ud-Din
  • Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune 411008, Maharashtra, India
E-mail:
Compilation of novel surfactant.protein mixtures has always been an intriguing and fascinating domain owing to their implications in industrial and cosmetic realms. In this regard, herein; we have synthesized a new cleavable gemini surfactant and investigated its influence on the structural characteristics of lysozyme via state-of-art techniques. Results have demonstrated the complex formation, unfolding and stabilization of lysozyme upon gemini surfactant combination. Docking/DFT has shown that gemini binds in the vicinity of hydrophobic residues (Trp/Tyr) and interacts via both electrostatic and hydrophobic contributions. This study may be significant to devise novel surfactant.protein mixtures for their end use at industrial stratum.
Keywords:C16-C4O2-C16;Lyz;Life time;AFM;Modeling;Industrial implications
  1. Wilcox M, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp.453 2000.
  2. McClements DJ, Food Emulsions: Principles, Practice and Techniques, 2nd ed., CRC Press, Boca Raton, FL, 2004.
  3. Jones MN, Chem. Soc. Rev., 21, 127 (1992)
  4. Jones MN, Food Polymers, Gels and Colloids, The Royal Society of Chemistry, Cambridge, U.K, pp.65 1991.
  5. Mishra M, Muthuprasanna P, Prabha KS, Rani PS, Babu IAS, Chandiran IS, Arunachalam G, Shalini S, Int. J. Pharmtech Res., 1, 1354 (2009)
  6. Martin VI, Rodriguez A, Maestre A, Moya ML, Langmuir, 29, 7629 (2013)
  7. Mahmoudi M, Lynch I, Ejtehadi MR, Monopoli MP, Bombelli FB, Laurent S, Chem. Rev., 111(9), 5610 (2011)
  8. Lynch I, Dawson KA, Nano Today, 3(1-2), 40 (2008)
  9. Hu W, Ding L, Cao J, Liu L, Wei Y, Fang Y, ACS Appl. Mater. Interfaces, 7, 4728 (2015)
  10. Yesilyurt V, Ramireddy R, Thayumanavan S, Angew. Chem.-Int. Edit., 50, 3038 (2011)
  11. Reddy R, Raghupathi R, Torres KR, Thayumanavan DA, Stimuli S, New J. Chem., 36, 340 (2012)
  12. Moriyama Y, Takeda K, Langmuir, 15(6), 2003 (1999)
  13. Mir MA, Khan JM, Khan RH, Rather GN, Dar AA, Colloids Surf. B: Biointerfaces, 77, 54 (2010)
  14. Tandon S, Horowitz P, J. Biol. Chem., 261, 15615 (1986)
  15. Tandon S, Horowitz P, J. Biol. Chem., 262, 4486 (1987)
  16. Rozema D, Gellman SH, J. Am. Chem. Soc., 117(8), 2373 (1995)
  17. Turro NJ, Lei XG, Ananthapadmanabhan KP, Aronson M, Langmuir, 11(7), 2525 (1995)
  18. Ghosh S, Banerjee A, Biomacromolecules, 3(1), 9 (2002)
  19. Ge YS, Tai SX, Xu ZQ, Lai L, Tian FF, Li DW, Jiang FL, Liu Y, Gao ZN, Langmuir, 28(14), 5913 (2012)
  20. Wang YS, Guo R, Xi JQ, J. Colloid Interface Sci., 331(2), 470 (2009)
  21. Wu D, Xu GY, Feng YJ, Wang YJ, Zhu YY, Colloid Polym. Sci., 287, 225 (2009)
  22. Mir MA, Khan JM, Khan RH, Rather GM, Dar AA, Colloids Surf. B: Biointerfaces, 77, 54 (2011)
  23. Faustino CMC, Calado ART, Garcia-Rio L, Biomacromolecules, 10(9), 2508 (2009)
  24. Menger M, Keiper JN, Angew. Chem.-Int. Edit., 39, 1906 (2000)
  25. Zana R, J. Colloid Interface Sci., 248(2), 203 (2002)
  26. Coleman D, Gathergood N, Chem. Soc. Rev., 39, 600 (2010)
  27. Ghosh A, Brinda KV, Vishveshwara S, Biophys. J., 92, 2523 (2007)
  28. Khan AB, Ali M, Malik NA, Ali A, Patel R, Colloids Surf. B: Biointerfaces, 112, 460 (2013)
  29. Paramaguru G, Kathiravan A, Selvaraj S, Venuvanalingam P, Renganathan R, J. Hazard. Mater., 175(1-3), 985 (2010)
  30. Dominguez A, Fernandez A, Gonzalez N, Iglesias E, Montenegro L, J. Chem. Educ., 74, 1227 (1997)
  31. Patial P, Shaheen A, Ahmad I, J. Surfact. Deterg., 17, 253 (2014)
  32. Wang L, Zhang Y, Ding L, Liu J, Zhao B, Deng Q, Yan T, RSC Adv., 5, 74764 (2015)
  33. Colomer A, Pinazo A, Garcia MT, Mitjans M, Vinardell MP, Infante MR, Martinez V, Perez L, Langmuir, 28(14), 5900 (2012)
  34. Aghdastinat H, Javadian S, Tehrani-Bagha A, Gharibi H, J. Phys. Chem. B, 118(11), 3063 (2014)
  35. Tawfik SM, J. Mol. Liq., 209, 320 (2015)
  36. Sheikh MS, Kabir-ud-Din, Dar AA, Colloids Surf. A: Physicochem. Eng. Asp., 378, 60 (2011)
  37. Akram M, Yousuf S, Sarwar T, Kabir-ud-Din, Colloids Surf. A: Physicochem. Eng. Asp., 441, 281 (2014)
  38. Stjerndahl M, van Ginke CG, Holmberg K, J. Surfact. Deterg., 6, 319 (2003)
  39. Zhinong G, Shuxin T, Qi Z, Yu Z, Bo L, Li H, Xiaoyan T, Wuhan Univ. J. Nat. Sci., 13, 227 (2008)
  40. Bhadani A, Endo T, Sakai K, Sakai H, Abe M, Colloid. Polym. Sci., 292, 1685 (2014)
  41. Aytun T, Mutaf OF, El-Atwani OJ, Ow-Yang CW, Langmuir, 24(24), 14183 (2008)
  42. Akram M, Bhat IA, Kabir-ud-Din, RSC Adv., 5, 102780 (2015)
  43. Tehrani-Bagha AR, Holmberg K, Materials, 6, 580 (2013)
  44. Naorem H, Devi SD, J. Surf. Sci. Technol., 22, 89 (2006)
  45. Menger FM, Mbadugha BNA, J. Am. Chem. Soc., 123(5), 875 (2001)
  46. Negm NA, Mohamed AS, J. Surf. Deterg., 11, 215 (2008)
  47. Chattoraj DK, Birdi KS, Adsorption and the Gibbs Surface Excess, Plenum Press, New York, 1984.
  48. Patra T, Ghosh S, Dey J, J. Colloid Interface Sci., 436, 138 (2014)
  49. Rosen MJ, Surfactants and Interfacial Phenomenon, 3rd ed., Wiley-Interscience, John Wiley & Sons, New York, 2004.
  50. Akram M, Bhat IA, Kabir-ud-Din, Int. J. Biol. Macromol., 78, 62 (2015)
  51. Akram M, Bhat IA, Bhat WF, Kabir-ud-Din, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 150, 440 (2015)
  52. Ray GB, Chakraborty I, Moulik SP, J. Colloid Interface Sci., 294(1), 248 (2006)
  53. Kamboj R, Singh S, Bhadani A, Kataria H, Kaur G, Langmuir, 28(33), 11969 (2012)
  54. Jaeger DA, Wang YP, Pennington RL, Langmuir, 18(24), 9259 (2002)
  55. Trillo JV, Meijide F, Tato JV, Jover A, Soto VH, de Frutos S, Galantini L, RSC Adv., 4, 6869 (2014)
  56. Tehrani-Bagha AR, Holmberg K, Langmuir, 26(12), 9276 (2010)
  57. Bhat IA, Bhat WF, Akram M, Kabir-ud-Din, Int. J. Biol. Macromol., 109, 1006 (2018)
  58. Sharma T, Dohare N, Kumari M, Kumar US, Khan AB, Patel R, RSC Adv., 7, 16763 (2017)
  59. Lakowicz JR, Principles of Fluorescence Spectroscopy, Plenum, New York, 1999.
  60. Ananthapadmanabhan KP, Goddard ED, Turro NJ, Kuot PL, Langmuir, 1, 352 (1985)
  61. Mir MA, Khan JM, Khan RH, Dar AA, Rather GM, J. Phys. Chem. B, 116, 5711 (212)
  62. Prieto G, Suarez MJ, Gonzalez-Perez A, Ruso JM, Sarmiento F, Phys. Chem. Chem. Phys., 6, 816 (2004)
  63. Messina PV, Prieto G, Ruso JM, Sarmiento F, J. Phys. Chem. B, 109(32), 15566 (2005)
  64. Chakraborty T, Chakraborty I, Moulik SP, Ghosh S, Langmuir, 25(5), 3062 (2009)
  65. Anand U, Jash C, Mukherjee S, J. Phys. Chem. B, 114(48), 15839 (2010)
  66. Anand U, Mukherjee S, Phys. Chem. Chem. Phys., 15, 9375 (2013)
  67. Mondal R, Ghosh N, Mukherjee S, Phys. Chem. Chem. Phys., 18, 30867 (2016)
  68. Mondal R, Ghosh N, Mukherjee S, J. Phys. Chem. B, 120(11), 2968 (2016)
  69. Nozaki Y, Tanford C, J. Biol. Chem., 246, 2211 (1971)
  70. Jacobs RE, White SH, Biochemistry, 28, 3421 (1989)
  71. Li SC, Deber C, Nat. Struct. Biol., 1, 368 (1994)
  72. O’Neil KT, DeGrado WF, Science, 250, 646 (1990)
  73. Cohen SR, Bitler A, Curr. Opin. Colloid Interface Sci., 13, 316 (2008)
  74. Inoue S, Uchihashi T, Yamamotob D, Andobc T, Chem. Commun., 47, 4974 (2011)
  75. Zhang R, Shi TF, An LJ, Huang QR, Macromolecules, 45(1), 555 (2012)
  76. Bastakoti BP, Ishihara S, Leo SY, Ariga K, Wu KCW, Yamauchi Y, Langmuir, 30(2), 651 (2014)
  77. Wu X, Dai C, Fang S, Li H, Wu Y, Sun X, Zhao M, Phys. Chem. Chem. Phys., 19, 16047 (2017)