The research was designed to synthesize novel single-atom silver-manganese nanocatalysts with a simple method for producing highly demanded ethyl glycolate (EGIy) and acetaldehyde diethyl acetal (ADA) by hydrogenating bioresources-derivable diethyl oxalate (DEO) under different temperatures. DEO conversions achieved with the catalyst are 80-100%. 100% EGly or 97% ADA selectivity was produced by simply tuning reaction temperatures. The single-atom silver-manganese nanocatalysts were formed through the entrance of Ag atoms into the lattice tunnels of hollandite-type manganese oxide (HMO) under H-2 reduction at 200 degrees C. The excellent activities of the nanocatalysts are mainly ascribed to the activation of H-2 and desirable chemical adsorption of DEO and ethanol. The EGIy was formed through the first order hydrogenation of DEO, while the ADA was obtained via the hydrogenation, dehydration and reaction. With the help of high-efficiency nanocatalysts, bioresources are promising raw materials for producing various high-value chemicals in environmentally responsible manners.