Nanostructured hybrid materials composed of inorganic and organic constituents of different chemistry and functionality have attracted wide range of biomedical applications. The uniform electrodeposition of polypyrrole into titania nanotube arrays was achieved by normal pulse voltammetry technique in lithium perchlorate electrolyte by varying the pulse period. The electrochemically assembled polypyrrole/titania nanotube arrays (PPy/TNTA) surface was characterized by structural characterizations including attenuated total reflectance-fourier transform infrared spectroscopy, Raman and X-ray photoelectron spectroscopy analysis. Morphological study carried out by high resolution scanning electron microscopy demonstrates the influence of varying pulse period in achieving the controlled deposition of polypyrrole into the nanotube frame work. Cyclic voltammetry study reveals the electroactive nature of the hybrid material. The contact angle measurements and In-vitro immersion studies in stimulated body fluid hanks' solution were carried out to evaluate the wettability and apatite forming ability of the developed hybrid material. The deposition of polypyrrole enhanced the corrosion resistance of TNTA as evidenced from the lower i(corr) value observed for PPy/TNTA. The corrosion protection behavior of the hybrid material revealed from the electrochemical impedance spectroscopic studies was clearly noticed from the increase in impedance and maximum phase angle values. Further In-vitro cell culture studies were carried out using MG63 osteoblast cells to evaluate the biocompatibility of the hybrid material. Noticeable improvement in corrosion protection and biocompatibility performance suggest the possible application of PPy/TNTA hybrid material for biomedical applications. (C) 2018 Elsevier B. V. All rights reserved.