In the present study, natural phyllosilicate clays, Illite and Montmorillonite, were stablished as efficient adsorbents for the removal of the ionic liquid 1-butyl, 2,3-dimethyl imidazolium chloride, achieving, respectively, 14 and 25 mg/g of adsorption. In addition, the regeneration of both adsorbents was hereby firstly performed by Fenton-based processes, using the catalytic action of the iron naturally present in clays. Two different reactor configurations, with regard to the ratio of adsorbent to liquid phase, were tested: fluidized and fixed bed reactors. The desorption equilibrium was the main limiting factor for the effective regeneration of the Illite clay by electro-Fenton process in the fluidized bed reactor. On the other hand, the fixed bed reactor, based on electrokinetic-Fenton phenomenon, proved to be suitable for the regeneration of the Montmorillonite clay and it would be an appropriate solution for the implementation of adsorbent regeneration by Fenton-based technology at large adsorbent/solution ratios. Both reactor configurations were suitable for the adsorbents regeneration, and 80% of ionic liquid degradation has been accomplished. Additionally, the adsorption capability of both clays was confirmed after the regeneration process, achieving almost the same initial uptake.