Monometallic and bimetallic catalysts (Pt, Ni, and Pt-Ni) with single support (Al2O3, TiO2) and composite support (CeO2/Al2O3, CeO2/TiO2) were prepared and tested for water-gas shift reaction in a tubular quartz reactor. Syngas and steam with different steam-to-carbon ratios served as feedstock. The operating pressure was fixed while the reaction temperature was varied. The measured results indicated that the monometallic Ni/Al2O3 catalyst exhibits the lowest CO conversion and H-2 yield as compared with other catalysts. About the same CO conversion can be obtained from Pt and Pt-Ni catalysts with single or composite support. However, higher H-2 yield can be achieved from the TiO2-supported catalyst compared with those supported by Al2O3. The experimental data also indicated that good thermal stability can be reached for the Pt-based catalysts studied.