In this paper, a novel anti-smudge coating cured by natural sunlight exposure or 35 s of UV irradiation was prepared. The coating shows highly transparency and it can be used in various substrates, including heat-sensitive materials. Besides, this coating repels against water, ink, cooking oil, crude oil, artificial fingerprint liquid, and protects substrates against strong acid, strong base, salt solution and organic solvent, indicative of striking self-cleaning and protective properties. And this coating can be used to fabricate anti-smudge products in various colors without compromising its anti-smudge properties. Optional curing strategies and rapid UV-curing property make this novel coating can be used in the special area.