This review focuses on the latest trends and advancements in microstructured reactors. With the recent drive towards the production of miniaturized systems, microstructured reactors have gained significant prominence in the chemical and process industries. Herein, we describe the fabrication, commercial aspects, design principles, and cutting- edge applications of microreactors. An overview of the significant areas of application under broad categories such as biological and pharmaceutical applications, inorganic and noble metal nanoparticles, and organic chemicals and polymers is also included. Finally, the article discusses future research prospects and key issues on microstructured reactors. (C) 2018 Elsevier Ltd. All rights reserved.