The Engine Combustion Network (ECN) Spray A target case corresponds to high-pressure liquid fuel injection in conditions relevant to diesel engines. Following the procedure by Wehrfritz et al. (2016), we utilize large-eddy simulation (LES) and flamelet generated manifold (FGM) methods to carry out an injection pressure sensitivity study for Spray A at 50, 100 and 150 MPa. Comparison with experiments is shown for both non-reacting and reacting conditions. Validation results in non-reacting conditions indicate relatively good agreement between the present LES and experimental data, with some deviation in mixture fraction radial profiles. In reacting conditions, the simulated flame lift-off length (FLOL) increases with injection pressure, deviating from the experiments by 4-14%. Respectively, the ignition delay time (IDT) decreases with increasing injection pressure and it is underpredicted in the simulations by 10-20%. Analysis of the underlying chemistry manifold implies that the observed discrepancies can be explained by the differences between experimental and computational mixing processes. (C) 2018 The Authors. Published by Elsevier Inc. on behalf of The Combustion Institute. This is an open access article under the CC BY-NC-ND license.