Transcritical CO2 refrigeration cycle integrated with mechanical subcooling (MS) cycle operating with zeotropic mixture is proposed in this study, based on the concept of Lorenz cycle. An energetic model is developed and analyses are conducted in detail. A maximum overall coefficient of performance (COP) is achieved at the optimum discharge pressure and optimum subcooling degree. The maximum overall COP, optimum subcooling degree and discharge pressure are closely related to the temperature glide of the mixtures. The energy efficiency of the transcritical CO2 refrigeration cycle can be efficiently improved, and the high pressure can be reduced when mixtures with proper temperature glide are used as MS cycle refrigerant. Compared with pure R32, the overall COP is enhanced by 4.91%, and the discharge pressure decreases by 0.11 MPa at evaporation temperature of -5 degrees C and ambient temperature of 35 degrees C when R32/R1234ze(Z) (55/45) is employed as MS refrigerant. The mixtures with proper temperature glide are recommended. The thermal performance of the overall cycle can be enhanced more significantly for hot and warm climate regions, or relative low evaporation temperature applications, though a high sub cooling degree is required to meet the optimum operation condition. (C) 2018 Elsevier Ltd. All rights reserved.