The aim of this work is to evaluate the performance of a gasoline engine using different fuel blends of propanol/gasoline. Set of laboratory tests were carried out to investigate the engine performance using four-stroke petrol engine under different operating conditions. The influence of various fuel blends of propanol/gasoline on the engine fuel consumption and its pollutants emission was investigated. The engine maps (fuel consumption & emissions) were used in vehicle simulation code so that the road vehicle performance within the cities according to a standard driving cycle could be determined. The results indicated that the use of propanol/gasoline fuel blend can improve the fuel economy by 2.84% for the blend ratio (propanol/gasoline 15%). Moreover, it decreases the pollutants emission of vehicle engine, especially hydrocarbon, carbon monoxide by 14.18% and 10.87% respectively. Also, the simulation results indicated that the vehicle fuel consumption is improved and the pollutants emissions of for carbon monoxide and hydrocarbon are decreased. (C) 2018 Elsevier Ltd. All rights reserved.