In this paper, the energy and exergy performance of several polygeneration arrangements driven by low and medium temperature geothermal resource is investigated. The aim is to assess and compare different coupling schemes, identifying suitable thermally driven technologies for each type of arrangement. The polygeneration system is intended to produce power, cooling and heat for direct uses by considering variations of series and parallel coupling schemes along with different alternatives of ORC and absorption cooling machines. The study was conducted considering a temperature range of low-to-medium geothermal resource from 80 degrees C to 150 degrees C. Mathematical models are developed based on first and second law of thermodynamics and solved by means of an equation solver. The results show a threshold temperature that makes a shift between feasible polygeneration arrangements and the type of thermally driven technologies adopted, resulting in two different polygeneration arrangements with highest energetic and exergetic performance. The first arrangement correspond to a temperature range that lies between 80 degrees C and 110 degrees C, and the second one between 110 degrees C and 150 degrees C. The poly generation arrangement with highest exergetic performance for the first range of temperatures was the hybrid parallel-series cascade arrangement (HPS2) having exergy efficiencies between 42.82% and 50.11%, while the one corresponding to the second temperature range was the series cascade arrangement (SC1) presenting exergy efficiencies from 51.44% to 52.9%. This effect is a consequence of the available temperature of the geothermal resource and the intrinsic energy performance of the different technologies considered. In regard to thermally driven technologies, arrangements where ORC and TDC subsystems are placed at the first thermal level, are the ones with the highest energetic and exergetic performance. Arrangements that have those components at the last level, present lowest performances.