Solar cooling is one of the most promising technologies for covering the increasing needs of our society with a clean and sustainable way. This paper examines an ejector-absorption cooling system operating with the LiBr-H2O working pair which is driven by parabolic trough solar collectors. The main objective of this investigation is to optimize the total solar cooling system and to compare it with the respective optimum system with conventional absorption chiller and parabolic trough collectors. The generator temperature and pressure, as well as the pressure drop in the ejector, are the optimization parameters, while the maximization of the system performance is the objective function. According to the final results, the system with the ejector leads to higher COP (coefficient of performance) for the majority of the examined operating scenarios. Moreover, the optimized ejector-absorption system presents performance enhancement up to 60.9% compared to the conventional absorption system for the case with 12.5 degrees C evaporating temperature and 30 degrees C condenser temperature. For this optimum case, the system COP is about 1.01, the chiller COP is 1.65 and the system exergy efficiency is 4.76%. Generally, the system COP is ranged from 0.473 to 1.01 for the system with ejector, while the demanded specific collecting area from 0.987 to 2.11 m(2)/kW(cooling). The analysis is performed with a developed model in Engineering Equation Solver which is validated with literature results.