The optimization criterion for designing the thermodynamic layout of an organic Rankine cycle is often based on either achieving maximum thermodynamic efficiency or incurring minimum initial specific investment costs. Such designs, however, need not lead to the maximum utilization of waste heat potential or an optimal investment. For full potential utilization of a waste heat source, its temperature should be brought down to near ambient temperatures via transfer of enthalpy to the organic Rankine cycle working fluid. In the limit, however, pursuit of complete source utilization may lead to capital intensive organic Rankine cycle layouts that demand infinitesimal temperature gradients in heat exchangers leading to massive heat transfer areas. This paper defines a new objective function that reveals the tradeoffs between specific investment cost and the extent to which waste heat is utilized. A particle swarm optimization algorithm is used to optimize 7 and 8 dimensional search space for pure and mixture based working fluids, respectively, for case studies involving power capacities of 5, 50 and 500 kWe, waste heat source temperatures ranging from 75 to 275 degrees C and a number of working fluids. As a practical aid to designers, a methodology for generating high isentropic efficiency scroll geometries corresponding to optimized cycles is presented, and the optimization analysis is further extended to solar thermal applications.