In this work, the oxidation properties of low-iron vanadium-titanium magnetite with high vanadium and titanium in a laboratory muffle furnace was investigated. XRD, SEM, and TG-DSC method are employed to identify the main phases and chemical composition of the samples. The roasting time of 4h and Na2CO3/vanadium titanium magnetite mass ratio of 7.5:100 were determined. The results showed that the blank oxidation roasting temperature ranged from 593 degrees C to 1035 degrees C, the mixed oxidation roasting temperature of vanadium-titanium magnetite and Na2CO3 at the range of 204 degrees C to 825 degrees C, and the forming temperature of soluble vanadate at the range of 700 degrees C to 825 degrees C. When roasting temperature reached 1000 degrees C, consolidation was started. When roasting temperature was 850 degrees C, the roasting conversion efficiency, acid leaching efficiency and water leaching efficiency were 92.4%, 87%, and 85%, respectively.