High-purity (>99.5%) O-2 production from air with silver-exchanged titanosilicates (Ag-ETS-10) using multiple single- and dual-stage vacuum swing adsorption (VSA) cycle configurations was investigated through process simulation, and optimization. Model predictions for the Skarstrom cycle were validated through experiments and an O-2 purity of 98.3 +/- 0.5% with a corresponding recovery of 10.6% was achieved. Oxygen purity-recovery Pareto fronts for the Skarstrom cycle and 6-step cycle with pressure equalization (PE) and heavy product pressurization (HPP) with dry air as the feed were obtained. The optimization predicted 82.0% O-2 recovery with a product purity of 99.5% for a 6-step cycle with PE and HPP and dry air feed stream. The effect of nitrogen content in the feed on the performance indicators was also studied. Operating conditions for various cycle configurations were optimized through nondominated sorting genetic algorithm technique to achieve low total energy consumption (592.4 kWh/tonne O-2) and high overall productivity (1.30 tonne O-2/m(3) Ag-ETS-10 day). The Pareto fronts of the single- and dual-stage configurations were compared against each other in order to choose the best possible design. The results indicated that the single-stage 6-step cycle with PE and HPP presents a better performance compared to the other single and dual-stage approaches. A simple graphical scheduling study was also conducted in order to calculate the number of columns required for a continuous process using the better performing configurations.