Unprecedented post-synthetic modification (PSM) applied on a new La-MOF containing Fe3O4 nanoparticles (NPs), via Schiff base build-up (with pyridine-2-carboxaldehyde) and PdCl2 coordination, proved to be an advantageous strategy to produce a superior heterogeneous catalyst for Suzuki-Miyaura C-C bond formation. The Fe3O4@La-MOF-Schiff base-Pd ensemble (characterized by PXRD, EDS, TEM, HAADF-STEM, VSM, TGA) showed very active, quite stable, magnetically recoverable and reusable in coupling of bromoor iodoaryls with arylboronic acids, affording practically quantitative yields of biaryls (>99%) and high TONs and TOFs. The catalyst has been recycled up to 12 times without significant loss of the catalytic activity. A synergistic cooperativity between Pd and the oxophilic La nodes, through the organic linker, is responsible for enhancing the catalyst activity and stability. (C) 2018 Elsevier Inc. All rights reserved.