The experimental solubility data of 2,6-dihydroxybenzoic acid in neat organic solvents and binary aqueous solvent systems at temperature range from (278.15 to 318.15) K have carefully been reanalyzed and some recommendations were proposed. In addition, a combined form of the Jouyban-Acree-van't Hoff model and the Abraham solvation parameters was used to predict the solubility of 2,6-dihydroxybenzoic acid in the binary solvent mixtures at various temperatures.