In this study, a distinctive hollow MgNi1.4Zn0.6/CaCu2.79Fe4.21O12 nanocomposite was synthesized for the first time using ultrasonic high-temperature spray pyrolysis method controlled at 1200 degrees C. Effect of various concentrations (0.01, 0.1, and 1 mol L-1) of the precursor solution on particle size and crystalline phase of nanocomposites was also analyzed. XRD and SEM results confirmed the difference in the particle size and crystalline pattern of the synthesized nanocomposite arisen due to the difference in concentrations. The results of antibacterial and antioxidant studies showed that the nanocomposites possessed remarkable antibacterial and antioxidant activities. Thus, the prepared hollow MgNi1.4Zn0.6/CaCu2.79Fe4.21O12 metal oxide nanocomposite via ultrasonic high-temperature spray pyrolysis can be an excellent material in various biomedical applications.