Cell performance of lithium-ion-batteries (LIB) can be tailored to particular hybrid or full electric vehicle applications by targeted adjustment of manufacturing parameters. Furthermore there is a large number of cathode material compositions which can be used. Knowing the correlations between these parameters, electrode structures and cell performance is important to reach the high requirements posed by electromobility. Within this study, impacts of essential manufacturing parameters, being active material mass loading, calendering stress load and carbon black content on the cell performance were investigated for two different, promising cathode materials. For NMC and LMO, the respectively highest calendering stress load and carbon black content yielded the best performance as losses due to poor electronic conductivity were reduced. The active material mass loading rather influenced the ratio between specific energy and specific power. Finally two optimally performing parameter configurations could be identified which were, depending on the required application: NMC with high mass loading and LMO with medium mass loading; in both cases the highest calendering load and carbon black content were applied. An analysis of statistical reproducibility dependent on various parameter configurations was carried out as well. A significant improvement of reproducibility could be achieved by increase of calendering stress load. (C) 2018 The Electrochemical Society.