3-D nanosheet arrays of Ni-3(VO4)(2) directly grown on Ni foam through a facile one-step hydrothermal route are used as an electrode for non-enzymatic glucose detection. The structure of Ni-3(VO4)(2) nanosheet arrays was confirmed by XRD, morphology by electron microscopy and chemical analysis using XPS. In the electrochemical studies, the sensitivity toward glucose sensing of Ni-3(VO4)(2) nanosheet arrays/ Ni foam was compared with bare Ni foam. The studies revealed Ni3(VO4) 2 nanosheet arrays/ Ni foam exhibited a remarkable high sensitivity of 19.83 mA mM(-1) cm(-2) with the response time of similar to 1 second and detection limit of 0.57 mu M. The amperometric response due to glucose and selectivity toward glucose electro-oxidation was excellent in the presence of interfering reagents such as ascorbic acid, uric acid, dopamine and L-cysteine. Further, the performance of the electrode in flexural conditions and issues such as reusability of the electrode and its application on real samples such as orange juice for glucose sensing have been demonstrated successfully. Overall results validated Ni-3(VO4)(2) nanosheet arrays/Ni foam electrode as an excellent candidate for glucose sensing, which is binder-free, and possesses high sensitivity and selectivity along with long term stability, good flexibility and reusability. (C) The Author(s) 2018. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives 4.0 License.