Simultaneous encapsulation of fluorescent dye molecules and crystallization of cyclodextrin-based metal-organic framework (CD-MOF) was carried out using the solution of the dye, gamma-cyclodextrin (gamma-CD) and KOH by vapoi diffusion method of methanol. Hydrophilic fluorescein (Flu) and rhodamine B (RhB) existed in the spherical nanopores at the center of primary (gamma-CD)(6) unit of CD-MOF. Isolated Flu and RhB molecules in CD-MOF emitted strong yellow and red fluorescence, respectively at the solid state due to the isolation of dye molecules in the nanopore. Optical properties of fluorescence resonance energy transfer were observed in doubel doped CD-MOF ot Flu and RhB. This means Flu and RhB molecules sit close to each other in the order of nanometers.