The transformation effects of metal ions and temperature on the DNA base guanine (G) metalorganic coordination motifs in water have been investigated by scanning tunneling microcopy (STM). The G molecules form an ordered hydrogen-bonded structure at the waterhighly oriented pyrolytic graphite interface. The STM observations reveal that the canonical G/9H form can be transformed into the G/(3H,7H) tautomer by increasing the temperature of the G solution to 38.6 degrees C. Moreover, metal ions bind with G molecules to form G(4)Fe(1)(3+) G(3)Fe(3)(2+) and the heterochiral intermixed G(4)Na(1)(+) metalorganic networks after the introduction of alkali-metal ions in cellular environment.