Polyamides belong to the major class of engineering polymers with very attractive properties but fail in a brittle manner under stress concentrators. PA6/ABS blends are well-established commercial materials due to their stiffness/toughness balance even when stress concentrators are present. The pair PA6/ABS is immiscible and exhibits poor mechanical properties due to unfavorable interactions, thus, an efficient compatibilization is mandatory for practical applications. Deep understanding of the processing-structure-properties interplays requires multiple characterization techniques to provide insights on the impact of the processing/compatibilization on morphology and phases' distribution. In this work an advanced co-localized AFM-Raman strategy was used to study the compatibilization of PA6/ABS blends with SAN-g-Maleic Anhydride. AFM and TEM allowed nanomechanical analysis and characterization of the blends' morphologies. Co-localized AFM-Raman provided new fundamental insights on the compatibilizer's effect on the PA6's gamma polymorphic crystallization. The amount and distribution of this gamma phase were found to depend on the blending protocol. (C) 2018 Elsevier Ltd. All rights reserved.