Hyaluronic acid-coated cisplatin conjugated gold nanoparticles for combined cancer treatment

Oyuntuya Gotov; Gantumur Battogtokh; Dongyun Shin; Young Tag Ko

Journal of Industrial and Engineering Chemistry, Vol.65, 236-243, September, 2018

DOI10.1016/j.jiec.2018.04.034 Export Citation

Hyaluronic acid-coated cisplatin conjugated gold nanoparticles for combined cancer treatment

Oyuntuya Gotov, Gantumur Battogtokh, Dongyun Shin, and Young Tag Ko^†

College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 406-799, South Korea

E-mail:

Gold nanoparticles are widely utilized for medical applications such as drug carriers and therapeutic and diagnostic agents due to their small size and great surface area. In the present study, we prepared hyaluronic acid-coated cisplatin conjugated gold nanoparticles to selectively deliver cisplatin into a tumor, and obtain synergistic effects using laser treatment. Our prepared hyaluronic acid-coated cisplatin conjugated gold nanoparticles were found to have a mean hydrodynamic diameter of approximately 140 nm and negative surface charge. The nanoparticles showed greater cytotoxicity than free cisplatin and in vivo antitumor efficacy in tumor models when near infra-red laser was applied. Therefore, this formulation could be applied for combined cancer therapy.

Keywords:Biopolymer coating;Gold nanoparticles;Cisplatin;Hyaluronic acid;Combined therapy

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[Referenced By]

[1] Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD, Small, 1, 325 (2005)

[2] Jelveh S, Chithrani DB, Cancers, 3, 1081 (2011)

[3] Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M, Langmuir, 21(23), 10644 (2005)

[4] Chithrani BD, Ghazani AA, Chan WC, Nano Lett., 6, 662 (2006)

[5] Jiang W, Kim BYS, Rutka JT, Chan WCW, Nat. Nanotechnol., 3(3), 145 (2008)

[6] Wang SH, Lee CW, Chiou A, Wei PK, J. Nanobiotechnol., 8, 33 (2010)

[7] Lu WT, Singh AK, Khan SA, Senapati D, Yu HT, Ray PC, J. Am. Chem. Soc., 132(51), 18103 (2010)

[8] de Castria TB, da Silva EM, Gois AF, Riera R, Cochrane Database Syst. Rev., 8, CD0092 (2013)

[9] Kelland L, Nat. Rev. Cancer, 7, 573 (2007)

[10] Wheate NJ, Walker S, Craig GE, Oun R, Dalton Trans., 39, 8113 (2010)

[11] Winton T, Livingston R, Johnson D, Rigas J, Johnston M, Butts C, et al., N. Engl. J. Med., 352, 2589 (2005)

[12] Casagrande N, Celegato M, Borghese C, Mongiat M, Colombatti A, Aldinucci D, Clin. Cancer Res., 20, 5496 (2014)

[13] Kelly K, Crowley J, Bunn PA, Presant CA, Grevstad PK, Moinpour CM, et al., J. Clin. Oncol., 19, 3210 (2001)

[14] Go RS, Adjei AA, J. Clin. Oncol., 17, 409 (1999)

[15] Stathopoulos GP, Anticancer Drugs, 21, 732 (2010)

[16] Brown TJ, Curr. Pharm. Biotechnol., 9, 253 (2008)

[17] Cai S, Alhowyan AA, Yang Q, Forrest WC, Shnayder Y, Forrest ML, J. Drug Target., 22, 648 (2014)

[18] Maiolino S, Moret F, Conte C, Fraix A, Tirino P, Ungaro F, Sortino S, Reddi E, Quaglia F, Nanoscale, 7, 5643 (2015)

[19] Orian-Rousseau V, Eur. J. Cancer, 46, 1271 (2010)

[20] Zoller M, Nat. Rev. Cancer, 11, 254 (2011)

[21] Simard J, Briggs C, Boal AK, Rotello VM, Chem. Commun., 1943 (2000).

[22] Wang Y, Wong JF, Teng XW, Lin XZ, Yang H, Nano Lett., 3, 1555 (2003)

[23] Carion O, Mahler B, Pons T, Dubertret B, Nat. Protoc., 2, 2383 (2007)

[24] Srinivasan C, Lee J, Papadimitrakopoulos F, Silbart LK, Zhao M, Burgess DJ, Mol. Ther., 14, 192 (2006)

[25] Luccardini C, Tribet C, Vial F, Marchi-Artzner V, Dahan M, Langmuir, 22(5), 2304 (2006)

[26] Yu WW, Chang E, Sayes CM, Drezek R, Colvin VL, Nanotechnology, 17, 4483 (2006)

[27] Mohamed T, Matou-Nasri S, Farooq A, Whitehead D, Azzawi M, Int. J. Nanomed., 12, 8813 (2017)

[28] Battogtokh G, Gotov O, Ko YT, Arch. Pharm. Res., 40, 356 (2017)

[29] Boyles MS, Kristl T, Andosch A, Zimmermann M, Tran N, Casals E, Himly M, Puntes V, Huber CG, Lutz-Meindl U, Duschl A, J. Nanobiotechnol., 13, 84 (2015)

[30] Guelfi G, Stefanetti V, Zampini D, Oommen OP, Brecchia G, Dall’Aglio C, Arcelli R, Cochetti G, Boni A, Mearini E, Sci. Rep., 7, 10355 (2017)

[31] Chen S, Lei Q, Qiu WX, Liu LH, Zheng DW, Fan JX, Rong L, Sun YX, Zhang XZ, Biomaterials, 117, 92 (2017)

[32] Golla ED, Ayres GH, Talanta, 20, 199 (1973)

[33] Sperling RA, Parak WJ, Philos. Trans. R. Soc. Lond. Ser. A-Math. Phys. Eng. Sci., 368, 1333 (2010)

[34] Wang F, Wang YC, Dou S, Xiong MH, Sun TM, Wang J, ACS Nano, 5, 3679 (2011)

[35] Yavuz MS, Cheng YY, Chen JY, Cobley CM, Zhang Q, Rycenga M, Xie JW, Kim C, Song KH, Schwartz AG, Wang LHV, Xia YN, Nat. Mater., 8(12), 935 (2009)

[36] Upadhyay KK, Bhatt AN, Mishra AK, Dwarakanath BS, Jain S, Schatz C, et al., Biomaterials, 31, 2882 (2010)

[37] Jin J, Krishnamachary B, Mironchik Y, Kobayashi H, Bhujwalla ZM, Sci. Rep., 6, 27871 (2016)

[38] Duan X, He C, Kron SJ, Lin W, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 8, 776 (2016)

[39] Duan X, Liu D, Chan C, Lin W, Small, 11, 3962 (2015)

[40] Ajnai G, Chiu A, Kan T, Cheng CC, Tsai TH, Chang J, J. Exp. Clin. Med., 6, 172 (2014)

[41] Dreaden EC, Austin LA, Mackey MA, El-Sayed MA, Ther. Deliv., 3, 457 (2012)

[42] Shao J, Griffin RJ, Galanzha EI, Kim JW, Koonce N, Webber J, Mustafa T, Biris AS, Nedosekin DA, Zharov VP, Sci. Rep., 3, 1293 (2013)