Crosslinked Polyphosphazene Nanospheres with Anticancer Quercetin: Synthesis, Spectroscopic, Thermal Properties, and Controlled Drug Release

Simge Metinoğlu Örü; Yasemin Süzen Demircioğlu

Macromolecular Research, Vol.26, No.8, 671-679, August, 2018

DOI10.1007/s13233-018-6092-2 Export Citation

Crosslinked Polyphosphazene Nanospheres with Anticancer Quercetin: Synthesis, Spectroscopic, Thermal Properties, and Controlled Drug Release

Simge Metinoğlu Örü^{1, 2}, and Yasemin Süzen Demircioğlu^{2, †}

¹Mehmet Akif Ersoy University, İstiklal Campus, Faculty of Science and Arts, Department of Chemistry, 15100, Turkey
²Yunusemre Campus, Faculty of Science, Department of Chemistry, Anadolu University, 26470, Turkey

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In this study, novel cross-linked inorganic-organic hybrid polyphosphazene nanospheres were synthesized via self-assembly precipitation polymerization between hexachlorocyclotriphosphazene (HCCP) as a crosslinker molecule and anticancer featured quercetin (QCT). The technique used for synthesizing QCT nanospheres is quite simple and rapid, and has some advantages like using just ultrasonic power. Furthermore, it does not require any surfactant or stabilizer. Growth of nanospheres and reaction time effect on the formation of QCT nanospheres were investigated. Quercetin and 4′,7-dihydroxyflavone were compared for the formation of nanospheres. The particle size of the spheres was determined to be approximately 434 nm by DLS (dynamic light scattering) measurements in 3 hours reaction time. The structure and morphology of synthesized QCT nanospheres were investigated by SEMEDX (scanning electron microscope) and XRD (X-ray diffractometer). The spectroscopic and thermal properties of cyclomatrix polyphosphazene QCT nanospheres were investigated by FTIR (Fourier transform infrared spectroscopy), UV-vis (ultraviolet-visible), fluorescence, and TGA (thermogravimetric analysis). Moreover, QCT nanospheres were used for controlled release of acriflavine which had been chosen as a model drug.

Keywords:quercetin;polyphosphazene;nanospheres;self-assembly;acriflavine;controlled release

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[6] Chen C, Zhu X, Gao Q, Fang F, Wang L, Huanget X, J. Mol. Catal. B-Enzym., 132, 67 (2016)

[7] Wei W, Lu RJ, Ye WT, Sun JH, Zhu Y, Luo J, Liu XY, Langmuir, 32(7), 1707 (2016)

[8] Wang X, Fu J, Chen Z, Li Q, Wu X, Xu Q, RSC Adv., 5, 33720 (2015)

[9] Wei W, Lu R, Xie H, Zhang Y, Bai X, Gu L, Da R, Liu X, J. Mater. Chem. A, 3, 4314 (2015)

[10] Fu JW, Chen ZH, Wu XC, Wang MH, Wang XZ, Zhang JH, Zhang JA, Xu Q, Chem. Eng. J., 281, 42 (2015)

[11] Qiu SL, Xing WY, Feng XM, Yu B, Mu XW, Yuen RKK, Hu Y, Chem. Eng. J., 309, 802 (2017)

[12] Wei W, Lu R, Tang S, Liu X, J. Mater. Chem. A, 3, 4604 (2015)

[13] Pan T, Huang X, Wei H, Wei W, Tang X, Macromol. Chem. Phys., 213, 1590 (2012)

[14] Wei W, Huang X, Chen K, Tao Y, Tang X, RSC Adv., 2, 3765 (2012)

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[19] Ozay H, Ozay O, Colloids Surf. A: Physicochem. Eng. Asp., 450, 99 (2014)

[20] Chang F, Huang X, Wei H, Chen K, Shan C, Tang X, Mater. Lett., 125, 128 (2014)

[21] Barreto ACH, Santiago VR, Mazzetto SE, Denardin JC, Lavin R, Mele G, Ribeiro NMPS, Vieira IGP, Goncalves T, Ricardo NMPS, Fechine PBA, J. Nanopart. Res., 13, 6545 (2011)

[22] Gao X, Zhang X, Zhang X, Wang Y, Sun L, Li C, J. Pharm. Pharmacol., 63, 757 (2011)

[23] Mukhopadhyay P, Prajapati AK, RSC Adv., 5, 97547 (2015)

[24] Kumari A, Yadav SK, Pakade YB, Singhc B, Yadav SC, Colloids Surf. B: Biointerfaces, 80, 184 (2010)

[25] Caddeo C, Nacher A, Diez-Sales O, Merino-Sanjuan M, Fadda AM, Manconi M, J. Microencapsul., 31(7), 694 (2014)

[26] Can HK, Karakus G, Tuzcu N, Polym. Bull., 71(11), 2903 (2014)

[27] Song S, Kwon OS, Chung YB, Xenobiotica, 35, 755 (2005)

[28] Gavini E, Sanna V, Juliano C, Bonferoni MC, Giunchedi P, AAPS Pharm. Sci., 3, 32 (2002)

[29] Patel H, Raval DA, Madamwara D, Patel SR, Angew. Makromol. Chem., 263, 25 (1998)

[30] Zhang P, Huang X, Fu J, Huang Y, Zhu Y, Tang X, Macromol. Chem. Phys., 210, 792 (2009)

[31] Zhang S, Zhao XS, Li B, Bai CY, Li Y, Wang L, Wen R, Zhang MC, Ma LJ, Li SJ, J. Hazard. Mater., 314, 95 (2016)

[32] Li C, Wang ZH, Yu DG, Williams GR, Nanoscale Res. Lett., 9, 258 (2014)

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[34] Fu J, Huang X, Zhua L, Tang X, Scr. Mater., 58, 1047 (2008)