RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent

Dahee Lee; Eunji Choi,; Jaewon Lee; Jungju Oh; Seonyeong Lee; Minhyung Lee

Journal of Industrial and Engineering Chemistry, Vol.67, 284-292, November, 2018

DOI10.1016/j.jiec.2018.06.040 Export Citation

RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: A RAGE-mediated gene carrier and an anti-angiogenic reagent

Dahee Lee, Eunji Choi,, Jaewon Lee, Jungju Oh, Seonyeong Lee, and Minhyung Lee^†

Department of Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea

E-mail:

Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25 kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an antiangiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy.

Keywords:Anti-angiogenesis;Gene delivery;Glioblastoma;Polyethylenimine;RAGE-binding peptide

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[1] Bierhaus A, Humpert PM, Morcos M, Wendt T, Chavakis T, Arnold B, Stern DM, Nawroth PP, J. Mol. Med., 83 (2005)

[2] Riehl A, Nemeth J, Angel P, Hess J, Cell Commun. Signal., 7 (2009)

[3] Xie J, Mendez JD, Mendez-Valenzuela V, Aguilar-Hernandez MM, Cell Signal., 25 (2013)

[4] Logsdon CD, Fuentes MK, Huang EH, Arumugam T, Curr. Mol. Med., 7 (2007)

[5] Chavakis T, Bierhaus A, Nawroth PP, Microbes Infect., 6 (2004)

[6] Blondonnet R, Audard J, Belville C, Clairefond G, Lutz J, Bouvier D, et al., Sci. Rep., 7 (2017)

[7] Chen X, Zhang L, Zhang IY, Liang J, Wang H, Ouyang M, Wu S, da Fonseca AC, Weng L, Yamamoto Y, Yamamoto H, Natarajan R, Badie B, Cancer Res., 74 (2014)

[8] Lee S, Piao C, Kim G, Kim JY, Choi E, Lee M, Eur. J. Pharm. Sci., 114 (2018)

[9] Maczurek A, Shanmugam K, Munch G, Ann. N. Y. Acad. Sci., 1126 (2008).

[10] Bucciarelli LG, Wendt T, Rong L, Lalla E, Hofmann MA, Goova MT, Taguchi A, Yan SF, Yan SD, Stern DM, Schmidt AM, Cell. Mol. Life Sci., 59 (2002)

[11] Yan SF, Ramasamy R, Schmidt AM, Nat. Clin. Pract. Endocrinol. Metab., 4 (2008)

[12] Wyss-Coray T, Rogers J, Cold Spring Harb. Perspect. Med., 2 (2012)

[13] Tang D, Kang R, Cheh CW, Livesey KM, Liang X, Schapiro NE, Benschop R, Sparvero LJ, Amoscato AA, Tracey KJ, Zeh HJ, Lotze MT, Oncogene, 29 (2010)

[14] DiNorcia J, Moroziewicz DN, Ippagunta N, Lee MK, Foster M, Rotterdam HZ, Bao F, Zhou YS, Yan SF, Emond J, Schmidt AM, Allendorf JD, J. Gastrointest. Surg., 14 (2010)

[15] Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P, Bierhaus A, Lotze MT, Zeh HJ, Cell Death Differ., 17 (2010)

[16] Zhao CB, Bao JM, Lu YJ, Zhao T, Zhou XH, Zheng DY, Zhao SC, Am. J. Cancer Res., 4 (2014)

[17] Kang R, Hou W, Zhang Q, Chen R, Lee YJ, Bartlett DL, Lotze MT, Tang D, Zeh HJ, Cell Death Dis., 5 (2014)

[18] Gebhardt C, Riehl A, Durchdewald M, Nemeth J, Furstenberger G, Muller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, Hess J, Angel P, J. Exp. Med., 205 (2008)

[19] Li W, Xu Q, Deng Y, Yang Z, Xing S, Zhao X, Zhu P, Wang X, He Z, Gao Y, Lab. Invest., 95 (2015)

[20] Hwang YH, Kim MJ, Lee YK, Lee M, Lee DY, J. Control. Release, 246 (2016)

[21] Oh B, Lee M, J. Control. Release, 175 (2014)

[22] Banerjee S, Kundu TK, Nucleic Acids Res., 31 (2003)

[23] Song JH, Kim JY, Piao C, Lee S, Kim B, Song SJ, Choi JS, Lee M, J. Control. Release, 234 (2016)

[24] Hong J, Ku SH, Lee MS, Jeong JH, Mok H, Choi D, Kim SH, Biomaterials, 35 (2014)

[25] Liang H, Zhong Y, Zhou S, Peng L, Cancer Lett., 313 (2011)

[26] DiNorcia J, Lee MK, Moroziewicz DN, Winner M, Suman P, Bao F, Remotti HE, Zou YS, Yan SF, Qiu W, Su GH, Schmidt AM, Allendorf JD, J. Gastrointest. Surg., 16 (2012)

[27] Lanati N, Emanuele E, Brondino N, Geroldi D, Curr. Vasc. Pharmacol., 8 (2010)

[28] Yamagishi S, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S, Expert Opin. Investig. Drugs, 17 (2008)

[29] Lee M, Rentz J, Han SO, Bull DA, Kim SW, Gene Ther., 10 (2003)

[30] Lemkine GF, Goula D, Becker N, Paleari L, Levi G, Demeneix BA, J. Drug Target., 7 (1999)

[31] Turunen MP, Hiltunen MO, Ruponen M, Virkamaki L, Szoka FC, Urtti A, Yla-Herttuala S, Gene Ther., 6 (1999)

[32] Nguyen HK, Lemieux P, Vinogradov SV, Gebhart CL, Guerin N, Paradis G, Bronich TK, Alakhov VV, Kabanov AV, Gene Ther., 7 (2000)

[33] Rhim T, Lee DY, Lee M, J. Control. Release, 172 (2013)

[34] Varda-Bloom N, Shaish A, Gonen A, Levanon K, Greenbereger S, Ferber S, Levkovitz H, Castel D, Goldberg I, Afek A, Kopolovitc Y, Harats D, Gene Ther., 8 (2001)

[35] Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, Buss S, et al., Circulation, 117 (2008)

[36] Helfrich I, Schadendorf D, Mol. Oncol., 5 (2011)