Cancer-targeted photothermal therapy using aptamer-conjugated gold nanoparticles

Eun Ji Hong; Yoon-Seok Kim; Dae Gun Choi; Min Suk Shim

Journal of Industrial and Engineering Chemistry, Vol.67, 429-436, November, 2018

DOI10.1016/j.jiec.2018.07.017 Export Citation

Cancer-targeted photothermal therapy using aptamer-conjugated gold nanoparticles

Eun Ji Hong, Yoon-Seok Kim, Dae Gun Choi, and Min Suk Shim^†

Division of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea

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Targeted intracellular delivery of therapeutic agents is one of the great challenges for cancer treatment. Aptamers that bind to a variety of biological targets have emerged as new targeting moieties with high specificity for targeted cancer therapy. In this study, near-infrared (NIR) light-absorbing hollow gold nanocages (AuNCs) were synthesized and conjugated with AS1411 aptamer to achieve cancer-targeted photothermal therapy. AuNC functionalized with PEG and AS1411 (AS1411-PEG-AuNC) exhibited selective cellular uptake in breast cancer cells due to selective binding of AS1411 to nucleolin, a protein that is over-expressed in cancer cells over normal cells. As a result, AS1411-PEG-AuNC showed cancer- targeted photothermal activity. This study demonstrates that aptamer-conjugated AuNCs are effective tumor-targeting photothermal agents.

Keywords:Aptamer;AS1411;Gold nanoparticle;NIR light;Photothermal therapy

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[Referenced By]

[1] Rajendran L, Knolker HJ, Simons K, Nat. Rev. Drug Discov, 9, 29 (2010)

[2] Brannon-Peppas L, Blanchette JO, Adv. Drug Deliv. Rev., 56, 1649 (2004)

[3] Peer D, Karp JM, Hong S, FaroKHzad OC, Margalit R, Langer R, Nat. Nanotechnol., 2(12), 751 (2007)

[4] Dhar S, Gu FX, Langer R, Farokhzad OC, Lippard SJ, Proc. Natl. Acad. Sci. U. S. A.

[5] Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, Marks JD, Benz CC, Park JW, Cancer Res., 66, 6732 (2006)

[6] Lu Y, Low PS, Adv. Drug Deliv. Rev., 54, 675 (2002)

[7] Lee TY, Lin CT, Kuo SY, Chang DK, Wu HC, Cancer Res., 67, 10958 (2007)

[8] Dapic V, Abdomerovic V, Marrington R, Peberdy J, Rodger A, Trent JO, Bates PJ, Nucleic Acids Res., 31, 2097 (2003)

[9] Keefe AD, Pai S, Ellington A, Nat. Rev. Drug Discov., 9, 537 (2010)

[10] Lee JH, Yigit MV, Mazumdar D, Lu Y, Adv. Drug Deliv. Rev., 62, 592 (2010)

[11] Soundararajan S, Wang L, Sridharan V, Chen W, Courtenay-Luck N, Jones D, Spicer EK, Fernandes DJ, Mol. Pharmacol., 76, 984 (2009)

[12] Bates PJ, Kahlon JB, Thomas SD, Trent JO, Miller DM, J. Biol. Chem., 274, 26369 (1999)

[13] Soundararajan S, Chen W, Spicer EK, Courtenay-Luck N, Fernandes DJ, Cancer Res., 68, 2358 (2008)

[14] Zou L, Wang H, He B, Zeng L, Tan T, Cao H, et al., Theranostics, 6, 762 (2016)

[15] Huang P, Rong P, Jin A, Yan X, Zhang MG, Lin J, et al., Adv. Mat., 26, 6401 (2014)

[16] Yang K, Zhang S, Zhang G, Sun X, Lee ST, Liu Z, Nano Lett., 10, 3318 (2010)

[17] Rao W, Deng ZS, Liu JA, Crit. Rev. Biomed. Eng., 38, 101 (2010)

[18] Cherukuri P, Glazer ES, Curley SA, Adv. Drug Deliv. Rev., 62, 339 (2010)

[19] Weissleder R, Nat. Biotechnol., 19, 316 (2001)

[20] Melancon MP, Zhou M, Li C, Accounts Chem. Res., 44, 947 (2011)

[21] Gobin AM, Lee MH, Halas NJ, James WD, Drezek RA, West JL, Nano Lett., 7, 1929 (2007)

[22] Huang XH, El-Sayed IH, Qian W, El-Sayed MA, J. Am. Chem. Soc., 128(6), 2115 (2006)

[23] Chen J, Saeki F, Wiley BJ, Cang H, Cobb MJ, Li ZY, Au L, Zhang H, Kimmey MB, Li X, Xia Y, Nano Lett., 5, 473 (2005)

[24] Chen J, Wang D, Xi J, Au L, Siekkinen A, Warsen A, Li ZY, Zhang H, Xia Y, Li X, Nano Lett., 7, 1318 (2007)

[25] Abbasian M, Mahmoodzadeh F, Salehi R, Amirsha A, New J. Chem., 41, 12777 (2017)

[26] Fay BL, Melamed JR, Day ES, Int. J. Nanomed., 10, 6931 (2015)

[27] Sun YG, Xia YN, J. Am. Chem. Soc., 126(12), 3892 (2004)

[28] Skrabalak SE, Au L, Li X, Xia Y, Nat. Protoc., 2, 2182 (2007)

[29] Carlsson J, Drevin H, Axen R, Biochem. J., 173, 723 (1978)

[30] Hurst SJ, Lytton-Jean AK, Mirkin CA, Anal. Chem., 78, 8313 (2006)

[31] Shoji Y, Akhtar S, Periasamy A, Herman B, Juliano RL, Nucleic Acids Res., 19, 5543 (1991)

[32] Shah NB, Vercellotti GM, White JG, Fegan A, Wagner CR, Bischof JC, Mol. Pharmaceutics, 9, 2146 (2012)

[33] Niidome T, Yamagata M, Okamoto Y, Akiyama Y, Takahashi H, Kawano T, et al., J. Control. Release, 114, 343 (2006)

[34] Lee KYJ, Wang Y, Nie S, RSC Adv., 5, 65651 (2015)

[35] Reyes-Reyes EM, Teng Y, Bates PJ, Cancer Res., 70, 8617 (2010)

[36] Engelberg S, Modrejewski J, Walter JG, Livney YD, Assaraf YG, Oncotarget, 9, 20993 (2018)

[37] Zhou J, Rossi JJ, Oligonucleotides, 21, 1 (2011)

[38] Ng CT, Tang FM, Li JJ, Ong C, Yung LL, Bay BH, Anat. Rec., 298, 418 (2015)

[39] Au L, Zhang Q, Cobley CM, Gidding M, Schwartz AG, Chen J, Xia Y, ACS Nano, 4, 35 (2010)

[40] Bates PJ, Laber DA, Miller DM, Thomas SD, Trent JO, Exp. Mol. Pathol., 86, 151 (2009)

[41] Choi EW, Nayak LV, Bates PJ, Nucleic Acids Res., 38, 1623 (2010)