Swellable-organically modified silica (SOMS) has been demonstrated to be an efficient catalyst scaffold for catalytic treatment of water contaminated with trichloroethylene (TCE). In this study, deactivation characteristics of Pd-incorporated SOMS for aqueous-phase hydrodechlorination (HDC) of TCE were investigated. Pd/SOMS catalysts were exposed to highly-concentrated chloride solutions (up to 1 M NaCl or 0.01 M HCl) to examine the deactivation resistant behavior of Pd/SOMS. The commonly used HDC catalyst Pd/Al2O3 was also studied for comparison purposes. Pd/SOMS and Pd/Al2O3 in their pristine and treated states were tested for aqueous-phase HDC of TCE and characterized by several techniques including N-2 physisorption, inductively coupled plasma optical emission spectroscopy (ICP-OES), X-ray photoelectron spectroscopy, extended X-ray absorption fine structure spectroscopy (EXAFS), and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) of adsorbed CO. The aqueous-phase treatments had a pronounced adverse effect on the textural properties of Pd/Al2O3, although the effect was independent of the type of the chloride precursor, NaCL or HCl. Treating Pd/Al2O3 with chloride-containing solutions lowered the catalytic activity due to formation of Pd-Cl complexes and active metal leaching. The leached Pd obtained from the treatment solution was shown to be inactive for aqueous-phase HDC of TCE. While Pd/Al2O3 underwent severe deactivation due to the chloride treatments, Pd/SOMS exhibited resistance to chloride deactivation and metal leaching. The chloride treatments did not impact the textural properties of Pd/SOMS. The achieved deactivation resistance was attributed to the novel characteristics of the SOMS support.