A pilot-scale anaerobic membrane bioreactor (AnMBR) was operated for 435 days in this study, aiming to treat pharmaceutical solvent wastewater containing m-Cresol (MC), isopropanol (IPA) and N,N-Dimethylformamide (DMF) pollutants at different temperatures of 35 +/- 3 degrees C, 25 +/- 3 degrees C, 15 +/- 3 degrees C and 25 +/- 3 degrees C, respectively. The reactor reached average total removal efficiencies of about 96%, 97.2% and 98% of MC, IPA and DMF at psychrophilic condition (15 +/- 3 degrees C). Higher physical removal rate was obtained at 15 +/- 3 degrees C due to the important contribution of membrane filtration. At this stage, the biogas production, methane content and specific methanogenic activity and extracellular polymeric substances of suspended sludge were observed with the lowest level. Moreover, the kinetic models for solvent degradation were established at different temperatures, results showed the smaller maximum specific substrate degradation rate of MC and IPA, besides, the lowest degradation rate of three solvents were obtained at 15 +/- 3 degrees C.