The solubilities of L-isoleucine and L-serine in aqueous sodium sulfate (Na2SO4) and potassium sulfate (K2SO4) from 298.15 to 308.15 K are presented. The solubilities are measured by 'gravimetric' method. The relative solubility of the amino acids is calculated to explain the salting-in and salting-out effect in the electrolytes solutions. The amino acids solvation thermodynamical parameters are computed. The chemical effects of the transfer Gibbs energies for both the amino acids are estimated by subtracting the cavity effect and dipole-dipole interaction effect from the total transfer energies. The chemical transfer energetics is employed to discuss solute-solvent and solvent-solvent interactions. (C) 2018 Elsevier B.V. All rights reserved.