An in-situ biosynthetic method was employed to prepare graphene-incorporated-bacterial-cellulose (G/BC) conductive nanohybrid. The electrical conductivity of G/BC was determined as high as 46 S/m. A G/BC-based heterogeneous catalyst, CoPc@G/BC, was fabricated by immobilizing tetraamino cobalt (II) phthalocyanine (CoPc) catalyst onto the G/BC nanohybrid. The catalytic activity of CoPc@G/BC, as determined by removal rate of rhodamine B (RhB) dye wastewater, was ca. 50% higher than that without graphene. Electron interaction between CoPc and graphene might be responsible for this enhancement.