A computational framework used to evaluate the aerodynamics and aeroacoustics is developed and validated against the experimental data in the previous work. In the present work, the different operating parameters of inlet flow velocity, tip speed ratio and turbulence intensity have been considered separately. The aerodynamic performance, the vortex dynamics and the aerodynamic acoustics of the full scale horizontal-axis wind turbine under different operating conditions have been investigated. And the analysis of the impact of different operating parameters is discussed. It is observed that the model has an extension to different conditions and it is sensitive and accurate for simulating the results of different condition parameters. According to the results, the wind with lower turbulence intensity will be better for the operating, and the wind turbine operation can be optimized by adjusting the rotating speed (TSR) according to the inflow wind velocity. In the end, a noise and power trade-off graphics has been proposed based on the wind turbine acoustics and performance results. With enough operating conditions available for reference, selecting the optimal operating parameters under specific operating conditions according to the noise and power trade-offs graphics becomes feasible. (C) 2018 Elsevier Ltd. All rights reserved.