An experimental and modeling study of the oxidation of acetylene-ethanol mixtures under high-pressure conditions (10-40 bar) has been carried out in the 575-1075 K temperature range in a plug-flow reactor. The influence on the oxidation process of the oxygen inlet concentration (determined by the air excess ratio, lambda) and the amount of ethanol (0-200 ppm) present in the reactant mixture has also been evaluated. In general, the predictions obtained with the proposed model are in satisfactory agreement with the experimental data. For a given pressure, the onset temperature for acetylene conversion is almost the same independent of the oxygen or ethanol concentration in the reactant mixture but is shifted to lower temperatures when the pressure is increased. Under the conditions of this study, the ethanol presence does not modify the main reaction routes for acetylene conversion, with its main effect being the modification of the radical pool composition.