Two novel cathode channel designs (multi-plates structure channel and integrated structure channel) are proposed and investigated by a three-dimensional multiphase numerical model. The numerical results indicate that the PEMFC with 30 degrees angle, 0.5 mm width and 6.0 mm distance of air-guide plates exhibits the best performance, and the effect of plates angle on PEMFC performance is most significant. Compared with the conventional channel, the novel channel designs are found to be capable of forcing more oxygen towards cathode catalyst layer (CCL) to improve the electrochemical reaction rate. In addition, these two novel channel designs are able to remove more liquid water from PEMFC to effectively avoid from water flooding. According to the simulation results, the maximum improvement of PEMFC net power densities for the multi-plates structure and integrated structure are 4.7% and 7.5%, respectively.